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Editor's Page

A Time for Reinvention

Submitted by redoxoma on
Image: Gerd Altmann, by Pixabay

Editor´s page by Francisco R. M. Laurindo and Flávia Meotti

Editorial

Few authors have been – most often indirectly - remembered during the Covid-19 pandemics as much as Gabriel Garcia-Marquez. Now and then we see everyone talking about "times of coronavirus", "times of Covid", "dystopic times", "exceptional times", "difficult times"and so on. As the world was taken by the corona storm, indeed we can talk about different times. Time for protecting ourselves, time for supporting others, time for discovering new challenges about self-isolation, time to turn on a survival mode, time to think collectively. For some of us, time to be healed or –sadly- time to mourn the loss of loved ones. For all, time to be resilient. For us immersed in science, time to fight for research support, time to fight ignorance, time away from the lab, time in the lab with coronavirus-related research, time supporting research agencies, time to talk about science, time for rethinking careers, time to keep the group united at a distance, time for science education...

For sure, each of us has been affected one way or another, most often radically, by this unusual and unexpected sequence of things. The main common denominator in this scenario is that this is a time for reinvention. Just as "doing our best" is to reinvent oneself at every moment, now it is time to rediscover, readapt and reshape ourselves. It is frequently said that the world will come back to the so-called "new normal". It is unclear whether a new normal will indeed be much different from prior times. Rather, the new normal may be more like reinventing peculiar and remarkably individual ways to reach the "old normal". Above all, in this process, this is a time for hope and to employ our science to try not to rely only on hope !

And, as the storm tries to settle, we come back with the Redoxoma Newsletter. And, of course, with a corona article – how could we not think about the related redox aspects? And we also bring (we apologize it is in spanish) the link to an interview with our well-known colleague Prof. Rafael Radi, a redox scientist at the front of Covid-19 fight organization in Uruguay.

Welcome !

The editors

Francisco R. M. Laurindo¹ and Flávia C. Meotti², Editors
¹Heart Institute (InCor), University of São Paulo Medical School, Brazil
²Institute of Chemistry, University of São Paulo, Brazil

Post image from Gerd Altmann by Pixabay licensed as Pixabay License

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Editorial

Submitted by redoxoma on
CEPID Redoxoma

Editor's page by Francisco R. M. Laurindo and Flávia Meotti

Time keeps going fast and 2019 advances quickly to its last third. So do our investigations, as you can see in this new issue of the Redoxoma Newsletter!

We start on the bright side of things, with a nice perspective on fluorescent probes to assess redox processes in biological systems, written by Dr. Marcelo Comini, our colleague from Uruguay.

We follow on form and function: a great highlight on the interplay between mitochondrial dynamic morphology and calcium uptake.

Then you should more than just say NO and read the highlight depicting innovative pathways of nitric oxide metabolism involving dinitrosyl iron complexes.

And we finish with a puzzle on useless trivia: which is the most frequent word in the title of Redoxoma papers? Read this essay to discover.

Francisco R. M. Laurindo¹ and Flávia Meotti², Editors
¹Heart Institute (InCor), University of São Paulo Medical School, Brazil ²Institute of Chemistry, University of São Paulo, Brazil

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Editorial

Submitted by redoxoma on
Foto: Marcos Santos/USP Imagens (sob licença CC BY-NC 3.0 BR)

Editor's page by Francisco R. M. Laurindo and Flávia Meotti

Welcome to our new issue of the Redoxoma Newsletter!

Challenges. We start with a frank talk by a young colleague which we believe will be quite appealing to our readers, both the youngs who face career challenges and the experienced investigators who face the challenge of supervising post-docs who face career challenges. Quite an important issue in our view and a major challenge for Brazilian science.

And we keep on challenges. This time a radical connection on the pathways of peroxynitrite reactivity and decomposition, involving the carbonate radical, very much an original Redoxoma contribution !

And we keep on original Redoxoma contributions. This time off the beaten track, on singlet oxygen and its implication on sepsis and inflammation.

And we keep on inflammation. This time discussing how neutrophils keep their balance and sum up on paradigms of redox signaling.

And we finish with a “D”. We invite to discover how.

Francisco R. M. Laurindo¹ and Flávia Meotti², Editors
¹Heart Institute (InCor), University of São Paulo Medical School, Brazil ²Institute of Chemistry, University of São Paulo, Brazil

Post image credits: Marcos Santos/USP Imagens under CC BY-NC 3.0 BR license.

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Editorial

Submitted by redoxoma on
Ed. December, 2018

Editor's page by Francisco R. M. Laurindo and Flávia Meotti

We have a varied menu to fulfill our scientific curiosity starting with a discussion on lipid redox code and the amazing variety of these compounds, which is just beginning to be scratched from the surface, as further exemplified by a Redoxoma work describing protein aggregation induced by lipid oxidation-derived aldehydes. We follow on interesting discoveries related to uric acid hydroperoxide functions.

The rest goes from fun to serious discussions, just as Science itself. We bring a list of the most popular redox genes, which you will find amusing and thought-provoking. The serious part follows our previous issues involving scientific publishing practices to discuss inconvenient but necessary thoughts about publications. Just as a reminder, the oppinions expressed in our articles represent the author's views and not those from Redoxoma.

Welcome to our Redoxoma Newsletter issue.

Francisco R. M. Laurindo¹ and Flávia Meotti², Editors
¹Heart Institute (InCor), University of São Paulo Medical School, Brazil
²Institute of Chemistry, University of São Paulo, Brazil

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Editorial

Submitted by redoxoma on

Editor's page by Francisco R. M. Laurindo

We are back after a longer while than we expected. As with redox processes themselves, this delay was caused by good and bad things. The bad ones were a recurrent problem with our server, which caused our Newsletter to repeatedly get out of access. Hopefully it will be stable from now on, just as we hope to happen with redox homeostasis. The good things were recurrent bouts of very very hard work for our Editor, as well as for our colleagues, as chairs and organizers of international meetings, editors, authors of original as well as review articles, assistants for our research agencies , etc in addition of course to the usual duties at our universities. Similar to redox processes, we hope that this stress can translate itself into a protective hormetic response that will keep us healthier and healthier. Indeed, this reflects the high speed at which our Redoxoma group keeps working and growing at all levels. And our enthusiasm, I believe. This is seen throughout this issue in the works that have appeared in press and are commented here, either a nice interview or as brief notes. And there are other works waiting to be discussed here, plus other ones in the pipeline. This number also brings some comments about good science practices – the importance of keeping a good lab notebook. And some critical discussion about impact factors which we borrowed (with kind permission) from Gregory Petsko and will hopefully ignite some controversy... Just as with redox processes, opposing pro and anti-forces determine the dynamic equilibrium and we hope that this discussion will motivate some colleagues to contribute with future notes to our newsletter. Welcome!

Francisco R. M. Laurindo, Editor in Chief of Redoxoma Newsletter
Heart Institute (InCor), University of São Paulo Medical School

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Editorial

Submitted by redoxoma on

Editor's page by Francisco R. M. Laurindo

Duality. That is the word of order of this issue of our Newsletter. Dual roles of enzymes as anti or prooxidants, dual roles of autophagy to protect or kill cancer cells, dual roles of redox processes to signal physiological processes or to contribute to disease-promoting mechanisms, and so on. Duality is not surprising, as we see that all along nature. But it is confusing to the scientist, who for sure would love to classify processes as either beneficial or damaging, given the pattern-seeking way our minds are structured. Things become even more confusing in the redox biology/chemistry area, given the several extra levels at which a given process can bifurcate across the “light-or-dark” decisions. It is up to us to crack these nuts in an intelligent way and to contribute to unravel these apparent paradoxes. And the way to do that in science involves seeking a mechanistic state of mind, as we discuss in our Redoxcope. For mechanisms are the true Science, allowing us to incorporate the fact that “….nothing is either good or bad, but thinking makes it so.” (William Shakespeare: Hamlet, Act 2, Scene 2, 239-251).

Francisco R. M. Laurindo
Editor in Chief of Redoxoma Newsletter

Heart Institute (InCor)
University of São Paulo Medical School, Brazil

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Editorial

Submitted by redoxoma on

Editor's page by Francisco R. M. Laurindo

It is exciting to realize that the Newsletter is establishing itself as a communication vehicle between the Redoxoma group and a now expanded array of colleagues from Brazil and abroad. Welcome to all of you. Thanks to the work of many colleagues, we have very exciting contributions, which emanate from research supported by our CEPID-Fapesp. In this issue, we can walk through intriguing paths, starting really from the beginning - with redox threads to the origin of life! And we end in a bold way, with a short essay from an experienced academic clinician, on how he interprets our redox area – leading us to think over where we should at the end direct our efforts. In between, we wander through intricate mechanisms in thiol-mediated signaling in bacteria, hormetic connections in yeast, mitochondrial morphology in stem cell fate, cholesterol in mitochondria, enzymatic thiol isomerase assays and interesting related issues. Moreover, we have two special reports, the first dealing with news from Redoxoma meeting with our Advisory Committee and the other a revealing interview with Prof. Etelvino Bechara, our long-term collaborator and a reference in redox biochemistry, which we had the kind permission of Revista da Fapesp to reproduce here. Welcome to the new issue of our Newsletter. We do hope you will feel encouraged to contribute to our future issues!

Francisco R. M. Laurindo
Editor in Chief of Redoxoma Newsletter

Heart Institute (InCor)
University of São Paulo Medical School

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Editorial

Submitted by redoxoma on

Editor's page
by Francisco R. M. Laurindo

I am very excited to present our second number of our Redoxoma Newsletter. You will soon notice why. First, we have grown bigger, indicating that this newsletter is already turning into a good vehicle for communicating ourselves around the science of redox processes. Second, we have exciting comments on scientific productions from our Redoxoma team, and I am glad to know we have even more in the pipeline. In addition, we bring selected highlights from the literature which are likely to be of interest to everyone. Remarkably, some of these were brought about by young investigators from our team. My special thanks to them: you are more than welcome and I warmly encourage others to follow your track! Our Redoxcope this time is a comment on thiol redox processes, brought about by Luis Eduardo Soares-Netto, which is particularly sharp and timely. I also gladly introduce the Education Page, with news from our Education branch led by Carmen Fernandez. Along the same line, new sections bringing clipping news (compiled by Flavia Meotti) and related events (compiled by Denise Fernandes) are presented. And more: I put together a short essay for the young and no-so-young colleagues, which I hope will make you think and help in mentorship. Everything was made possible with the dedicated work of all the contributors and Leandro de Rezende, who gave life to these letters. Thank you all! Hope you will enjoy this Newsletter and feel inspired to contribute more and more to our next issues. Francisco RM Laurindo Editor, Redoxoma Newsletter

Francisco R. M. Laurindo
Editor, Redoxoma Newsletter

Instituto de Coração, Faculdade de Medicina
Universidade de São Paulo

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Welcome to the Cepid Redoxoma Newsletter!

Submitted by redoxoma on
Welcome to the CEPID Redoxoma Newsletter

Editor’s Page

Welcome to the Cepid Redoxoma Newsletter!

Science is all about communicating Science. From a single discovery to an ellaborated theory, nothing exists unless it is effectively communicated and published. But this is not enough, particularly considering the explosive amount of information one is exposed nowadays. Discoveries and theories have to be actively and widely disseminated. Moreover, communication is the only means for cross-fertilization and collaboration, the hallmarks of high-impact modern Science. The main purpose of our CEPID-Redoxoma is to build a network that allows interaction and synergism.

Effective communication, thus, is at the heart of our aims as a group and, at the same time, is important to expose our work to the external scientific community and to other segments of society, particularly those connected with technology and innovation. This Newsletter aims to be an instrument contributing to the exchange of information and dissemination of our activities and achievements.

The main feature of our Newsletter is its flexible structure, allowing to accommodate distinct types of contributions, which we are ready to implement over time. We will have invited comments from experts, summary from articles published by Redoxoma members, comments on other articles, clipping News and an agenda for events and opportunities (such as available PhD or post-doctoral trainings). The “Radical-free corner” is a site for open discussion on burnig issues of Science. We will also feature Education and Innovation pages in future issues. We highly wellcome comments from all colleagues and students on essentially any topic related to Redoxoma activities.

We wish this Newsletter will help enhancing our interaction as a group and our overall visibility. You are more than wellcome to be part of it!

Francisco RM Laurindo
Editor, Redoxoma Newsletter
Instituto do Coração,
Faculdade de Medicina da Universidade de São Paulo