Peroxide signaling through thiol switches: chemical and biological aspects.

by Luis E. S. Netto

It is now well accepted that oxidants and other redox intermediates are not only damaging compounds, but also act as signaling molecules. This is especially evident for hydrogen peroxide, whose generation and degradation are finely regulated through multiple enzymatic systems. Proteins whose activities are based on Cysteine (Cys) residues are frequently reported to be oxidized in various biological systems in conditions where hydrogen peroxide is also generated. As the most parsimonious hypothesis, these proteins are frequently assumed to be directly oxidized by hydrogen peroxide, although this is not always supported by chemical data.

For instance, Protein Tyrosine Phosphatases

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