Superoxide and nitric oxide induced nitrosative processes may follow unusual and different dynamic behaviors

by José Carlos Toledo

Possibly, most pathophysiological processes involving the radicals nitric oxide (NO•) and superoxide (O₂•–) depend on their simultaneous production and their favorable co-reaction to produce peroxynitrite. Peroxynitrite is an oxidant itself but in the presence of carbon dioxide it gives origin to radical species such as carbonate anion (CO₃•–) and nitrogen dioxide (NO₂•) radicals, both capable of stimulating oxidative and nitrosative events that damage biomolecules. The interplay of NO• and O₂•– in biological environments is complex, though. Using a fluorescent probe molecule to