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The "D" of CEPID

Submitted by redoxoma on Wed, 05/15/2019 - 18:58
"D"

Education Page by Carmen Fernandez
Corresponding author e-mail: carmecarmeqn@hotmail.com@iq.usp.br

The most important attribute of the special program CEPID [1] (Centros de Pesquisa, Inovação e Difusão, or RIDC, Research, Innovation, and Dissemination Centers) is the multiplicity of its missions. Thus, in addition to the primary mission of developing research on specific themes, CEPID´s are characterized by the development of effective mechanisms of Technology Transfer and Education and Knowledge Diffusion. In this article, we focus on the mission of Education and Diffusion of Knowledge of Redoxoma [2], translated by D from CEPID. A careful reading of Fapesp's 2011 initial public announcement [3] reveals that what is expected in D encompasses quite diverse actions such as:

[...] centers must maintain diffusion activities and contribute to the improvement of science education; [...] they should contribute to the scientific education of children and young people, in the activity of scientific diffusion, be it interacting with schools or interacting directly with the general public; [...] in addition to performing extension activities in the area of basic education, such as scientific initiation for students and teachers of high school, teacher training and courses of scientific diffusion.

Difficult to translate all this into a simple D. In fact, what is intended are educational actions, both in the contact with students of basic education and with the general public, promotion of professional development of teachers in addition to actions to raise public understanding of science. Apart from the question of covering several actions in D, it is worth taking advantage of this space to address the issues of ambiguities that usually appear with the terms Diffusion / Dissemination. And in the sequence we will deal with the D actions of Redoxoma. Difusão incorporates Divulgação científica, Disseminação científica and Jornalismo científico itself

The D in the English version of the Fapesp website [1] is treated as Dissemination and in the Portuguese version it is translated as Difusão (Diffusion). Beyond the different words for the English terms - diffusion, dissemination, public awareness of Science (PAwS), public understanding of science (PUS), or more recently, Public Engagement with Science and Technology (PEST), among others, there are also ambiguities of the terms in the Portuguese language - the terms Difusão, Disseminação and Divulgação are often used as synonyms. So it is worth treating these differences of the terms in Portuguese, although this text is written in English. In an attempt to make it clearer we will use the Portuguese terms in italics to avoid generating more misunderstandings.

According to Bueno [4] Difusão is the broader term and refers to any and all processes or resources used for communicating scientific information. Thus, Difusão incorporates Divulgação científica, Disseminação científica and Jornalismo científico itself (Figure 1). What changes is the target audience and therefore the level of language used. If the Difusão is made for experts, it is called Disseminação científica and occurs with specific technical terms of a given area (for example it is what occurs in conferences and scientific articles), if it is made for the general public it is called Divulgação científica (communicating science to public understanding). The latter presupposes a recoding of the specialized language of the experts into a language comprehensible to a non-specialist audience [5], for instance, videos, texts, explanatory health campaigns, textbooks, documentaries, etc. Also, there is the term Jornalismo científico (Science journalism) that is used when the article dealing with science is written by a journalist.

Difusão Científica

Figure 1. Differences between the terms Difusão, Divulgação, Disseminação Científica and Jornalismo Científico.

Thus, in D of CEPID several activities are being included as the Disseminação científica (represented by the articles and lectures of scientists for public experts and also, this newsletter [6] that is another channel for the dissemination of Redoxoma researches), Divulgação científica (to students and non-specialized audiences), and Jornalismo científico (from articles produced for the Redoxoma website) as well as several other actions related to basic education and teacher training activities. And in this range of activities under the letter D from our CEPID Redoxoma, are also included activities of educational research that feedback our Divulgação actions.

Now we will focus specifically on the D actions of Redoxoma. It is noteworthy that the research of CEPID Redoxoma focuses on the redox mechanisms involved in cellular homeostasis and pathologies, with emphasis on chronic-degenerative diseases, such as cardiovascular, metabolic and inflammatory diseases. Thinking about the Difusão actions students have problems in associating the concept of oxireduction reactions with the context of the day to day and the contact with the basic education and the training of teachers, the chemical content that connects all of this is oxidation reactions or more generally speaking, redox processes.

In this sense, the approach of our group is to connect all these activities - educational research, teacher training, and Difusão Científica. It starts from educational research to investigate the difficulties with understanding the redox subject at all levels in order to adopt the best strategies, resources, and language, and we arrive at the development of proposals that take into account the difficulties with this subject. The activities developed are a backdrop for further educational research to be carried out.

Speaking briefly of the difficulties with this subject, students have problems in associating the concept of oxireduction reactions with the context of the day to day, in spite of the importance of the redox processes and their daily applications. On the other hand, some teachers find the subject difficult to teach, and because of this, they feel that lesson plans are difficult to prepare. In chemistry teaching in general and in teaching redox processes in particular, students have many difficulties in traffic that scientists easily make between the macroscopic (the phenomenon), submicroscopic (particles and their arrangement) and symbolic levels (formulas, chemical equations, signal charges, etc.), see figure 2. In addition, there are problems with the coexistence of several explanatory models, with the understanding of the simultaneity of oxidation and reduction reactions, with a confusion between the language used in physics for electrical circuits and that of chemistry when dealing with cells and batteries, among many others.

Difusão Científica

Figure 2. Johnstone's model of the three levels of Chemical Knowledge [7].

Our group has developed several analyzes with the teaching of redox processes and brought this knowledge to Divulgação actions, production of didactic resources, courses for teachers and content for the media. Some of the group actions will be mentioned here. We analyzed the difficulties with the school redox content in the Brazilian context and analyzed textbooks approved by the federal government and used in all basic education (from the first to the ninth year of elementary school and in the three years of high school). Subjects such as cellular respiration, photosynthesis, cells and batteries, rust and combustion already appear in the first years of the elementary school in a more contextualized and phenomenological way and are increasingly being formalized and translated into a submicroscopic and symbolic level in High School. The visual representations in the books were a specific theme of analysis and what is observed is an excessive valuation in the books of representations at the macro level (mainly pictures) and in much smaller quantity appear the representations at the submicroscopic and symbolic level (Figure 3). And still in smaller numbers appear representations in which the three different levels of the chemistry are contemplated. There are no explanations on how to move between these different levels and this is a task that is left to the teacher. It turns out that we have also analyzed teacher's classes in this aspect and what we observe is that the teacher transits between these levels as if it were obvious to his students. In the textbooks are perceived representations and texts that end up emphasizing still more the difficulties of the students. The group has also produced didactic resources that take into account the difficulties pointed out. Thus, simulators, videos, and games were produced and made available on the Labiq [8] website. The group also developed and offered several courses for teachers that showed this repertoire of difficulties, textbooks, and student resources.

(A) Macroscopic level, (B) Submicroscopic level, (C) Macroscopic and Symbolic level

Figure 3. Examples of textbook representations at (A) Macroscopic level, (B) Submicroscopic level, (C) Macroscopic and Symbolic level.
Santos, W. L. and Mól, G. S. (2013). Química Cidadã (2ed. Vol.3). São Paulo: AJS Ltda. Reproduced by permission of AJS Ltda, São Paulo, São Paulo.

In terms of Divulgação, Redoxoma has regularly participated in lecture programs in public places intended for general audiences. Examples are: Pint of Science [9] (presentations of scientists in bars), Chemistry is life (lectures by scientists at the Mário de Andrade Library [10]), Chemistry Week [11] at IQ-USP, 24 hours of Science [12], USP Science and Technology Week [13], National Science and Technology Week [14], among others. An exhibition was produced for the São Paulo subway on Aging and was developed a site named Free and Radicals [2,15] with explanatory material. Content was also produced for the media (Jornalismo científico) where research activities related to technology transfer and education and Divulgação científica are made available to the public through articles published on the Redoxoma´s website [2], shared on the Facebook page [16] and distributed as a press release for Fapesp Agency [17] and the Journal of USP [18]. This material generated new reports and videos, expanding the Divulgação of Redoxoma.

In terms of training of people for the Chemical Education area, six masters dissertations and nine doctoral theses were defended in the group since the project start (2012) and three master's degrees and nine doctorates are in progress. Lists of these surveys and publications are presented on the Redoxoma website in the annual report tab [19], Labiq [8] and PEQuim (Pesquisa em Ensino de Química, Research in Chemistry Teaching) group’s page [20].


References

  1. FAPESP. Centros de Pesquisa, Inovação e Difusão (Homepage)url: http://cepid.fapesp.br/home/
  2. CEPID Redoxoma. Centro de Pesquisa em Processos Redox em Biomedicina (Homepage)url: http://redoxoma.iq.usp.br/
  3. FAPESP. Edital CEPID 2011url: http://www.fapesp.br/6335
  4. W. da C. Bueno. Jornalismos científico: coneceitos e funções Ciência e Cultura, 9(37): 1420-1428, 1985.url: http://www.scielo.br/scielo.php?script
  5. J. M. M. Loureiro. Museu de ciência, divulgação científica e hegemonia Ciência da Informação, 32(1): 88–95, 2003. | doi: 10.1590/s0100-19652003000100009
  6. CEPID Redoxoma. Redoxoma Newsletter (Homepage)url: http://redoxomanewsletter.iq.usp.br/
  7. A. H. Johnstone. Why is science difficult to learn? Things are seldom what they seem Journal of Computer Assisted Learning, 7(2): 75–83, 1991. | doi: 10.1111/j.1365-2729.1991.tb00230.x
  8. LABIQ. Laboratório Integrado de Química e Bioquímica (Homepage)url: http://labiq.iq.usp.br/
  9. Pint of Science. Pint of Science Brasil (Homepage)url: https://pintofscience.com.br/
  10. Prefeitura de SP. Biblioteca Mário de Andrade (Homepage)url: https://www.prefeitura.sp.gov.br/cidade/secretarias/cultura/bma/
  11. Instituto de Química - USP. Semana da Química (Homepage)url: http://www.iq.usp.br/semanadaquimica/
  12. USP. Virada Científica (Homepage)url: https://www5.usp.br/tag/virada-cientifica/
  13. PRCEU-USP. Semana USP de Ciência e Tecnologia 2018 (Homepage)url: http://prceu.usp.br/noticia/ciencia-e-tecnologia-na-usp-2018/
  14. MCTIC. Semana Nacional de Ciência e Tecnologia 2019 (Homepage)url: http://snct.mctic.gov.br/portal
  15. CEPID Redoxoma. Livres e Radicais: Química, vida, saúde e radicais livres (Homepage)url: http://livresradicais.iq.usp.br/
  16. CEPID Redoxoma. Centro de Pesquisa em Processos Redox em Biomedicina (Canal do Facebook)url: https://www.facebook.com/redoxoma/
  17. FAPESP. Agência Fapesp (Homepage)url: http://agencia.fapesp.br/inicial/
  18. USP. Jornal da USP (Homepage)url: https://jornal.usp.br/
  19. CEPID Redoxoma. Relatório Anual de Atividades (CEPID Redoxoma),url: http://redoxoma.iq.usp.br/paginas_view.php?idPagina
  20. C. Fernandez. PEQuim - Grupo de Pesquisa em Ensino de Química - USP (Homepage)url: https://sites.usp.br/pequim/

Carmen Fernandez, Ph.D. Associate Professor at Department of Fundamental Chemistry,
Institute of Chemistry, University of São Paulo, Brazil


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Overcoming professional challenges as a young scientist

Submitted by redoxoma on Wed, 05/15/2019 - 18:00
Young scientist

Main Article by Gustavo G Belchior from Core Us Consultoria e Comunicação Científica
Corresponding author e-mail: gust-I-am-here-avo@hotmail.com@coreus.com.br

Making a clear career choice at any given time is no easy task for most of us. Just as challenging is knowing if a certain choice will bring us closer to success before the resulting outcomes are tangible. For graduate students, establishing a professional horizon can be especially difficult when trying to decide between the ‘rights’ and ‘wrongs’ of staying in academia or aiming for different horizons.

Academic research is enthralling to many. Being surrounded by an environment where thirst for knowledge is a priority resonates deeply within those who thrive on applying the scientific method to uncover our universe. Feeling useful to society is undoubtedly a big driver Be it in a new field of basic research in materials engineering or the final stages of developing a promising biopharmaceutical, the discovery process gives graduate students meaning as they realize their work and effort can meet world needs. Feeling useful to society is undoubtedly a big driver and a great source of strength against the adversities that coexist. Most of the times, however, building the ‘knowledgeable-to-useful’ bridge is not so obvious and ends up being very demanding and under the influence of several aspects, including the project, the PI, and the research group. Having to deal with exams, report and manuscript deadlines, and coming up with hypotheses and complex experiments to generate plausible conclusions requires a diverse range of specific skills and virtues, including being able to handle the controllable and uncontrollable aspects that permeate research. Notwithstanding, migrating to a position in the private sector or bringing an idea to life as an entrepreneur poses its own obstacles.

The corporate rhythm is dictated by aggressive goals that are often set by the higher managerial levels and cascaded down to company employees. For those companies that filed for an IPO (Initial Public Offering), decisions are thoroughly appraised by investors that help shape the future of the organization. When the need for change is perceived, even the simplest transitions – such as updating a software – may require a considerable amount of energy given the great inertia of the whole corporate body. On the other hand, startups present themselves as fast-paced vehicles that entrepreneurs get to drive. Shifting gears becomes as natural as breathing for founders and their teams, accustomed to a culture more open to failure and that encourages constant pivoting to quickly improve prototypes and MVPs (Minimal Viable Products). When it comes to transforming an idea into a business, a lot of effort goes into structuring the three pillars that investors will keep an eye on: people/team, product/service, and market size. This specific context plays with creativity and intensely explores the possibilities of the unknown, creating a scenario fit for adrenergic explorers.

Information Age must be taken into consideration as well. It is upon us at crushing intensity and resulting in an increased VUCA (Volatile, Uncertain, Complex, Ambiguous) [1] environment, making it even harder for a conscious decision to be made towards the next professional step. As big data predictions indicate over 40 zettabytes (zetta = 1021) of data will be available by 2020 [2], the combination of possibilities to the human mind in terms of building a career is overwhelming. Importantly, struggles with this process do not initiate at the graduate level. Many undergraduate students also face challenges with persisting in their courses in several areas and countries, leading to dropout rates of concerning proportions [35]. Nevertheless, young graduated researchers are facing issues in a very particularly setting.

Academia competition is intensifying. Since the late 1980’s, some areas have seen a radical increase in Ph.D. graduation rates contrast with a decrease in the number of tenure-track faculty members [6]. Data from the Survey of Doctorate Recipients conducted by the U.S. National Science Foundation showed a drop of 10 percentage points in the number of Ph.Ds. that held a tenured or tenure-track position comparing 1997 to 2017 (33% vs. 23%) [7]. According to a report from London’s Royal Society, 3.5% of graduates remain in university and only 0.5% will become professors [8,9], an unbalanced proportion that might explain the psychological consequences graduate students are suffering from [1013]. While more funding for scientific projects and permanent jobs in academia would alleviate this condition in detriment of institutional budget, some suggest data might also lead the way to a solution through record tracking of job positions. This would provide information which could be made available to help candidates get clearer perspectives regarding academic opportunities [14]. holding a M.Sc. or Ph.D. title does guarantee advantages in the corporate world Despite the complexity of academic careers, holding a M.Sc. or Ph.D. title does guarantee advantages in the corporate world in every medium. As ironic as it may seem, in some countries a higher educational degree decrease the chances for hiring. While the average global unemployment rate among masters and doctors revolves around 2%, in Brazil 25% of these professionals are out of a job [15] – which represents more than twice the unemployment rate for those who do not carry these titles. Conversely, the U.S. job market has never hired as many Ph.Ds. in science and engineering7, generating a stimulus for the migration of highly-capacitated individuals.

This apparently unfavorable situation requires identifying a common denominator and a resolution that comes regardless of aspects that are considered disadvantageous. For one, all these factors are exogenous and subjected to individual perception. Therefore, appreciation or devaluation of external conditions will greatly vary among students, as will their individual meaning of success. Etymologically, success derives from the Latin word succedere, which means ‘to succeed’ or ‘come after”. This automatically implies that a predecessor must exist, one that should be established before any professional step is taken but is frequently taken for granted: a purposeful objective.

Without clearly establishing what has meaning in the professional realm, even the brightest, most yielding graduate student will not be able to discern between staying in academia, searching for a job, or starting a business – or any of the many other limitless possibilities. As occupational personas can have multiple interests (e.g., Da Vinci, Thomas Edison), a successful path will derive from what professionals assimilate as their own challenge, a cause they want to fight for, and a need their virtues can meet. Hopefully, there are many tools that can be used to aid early researchers in this process. From journal columns [16] to podcasts [17], several resources are packed with information specifically directed to scientific careers, including an emerging number of articles providing graduates with elements for their decision-making process [1821]. Interestingly, some established practices from the corporate world, such as mentoring, may be useful for academics [22], as well as coming up with specific career strategies and balancing planning, uncertainty, achievements, and perceived failures [8, 23].

Each graduate student is unique and has a very broad skill set Each graduate student is unique and has a very broad skill set that can be utilized in many different endeavors. After all, the young scientist has potential to become a brilliant prolific PI, an outstanding goal-oriented company manager, or an amazing startup leader who will create the next unicorn. The three Vs of our time (Volume, Velocity and Variety) will nonetheless require M.Sc. and Ph.D. candidates to dominate those external factors and focus on their virtues to make educated, conscious career decisions. Ultimately, since choosing a certain professional path is a very personal and intimate process, ‘rights’ and ‘wrongs’ are relative judgements that do not preponderate over an authentic, purposeful objective that will more likely bring success to those who define it.


Gustavo Belchior (gus-I-am-here-tavo@hotmail.com@coreus.com.br) holds a B.Sc. in Biology (2007) and a Ph.D. in Biochemistry (2014) from the University of São Paulo, with a research period at the Children’s Hospital Los Angeles (Keck School of Medicine, University of Southern California). He served as Regulatory Affairs Specialist at Monsanto (2013-2017), working on petitions for the commercial release of biotechnology-derived crop products. He founded and is the current CEO (since 2017) at Core Us Consultoria e Comunicação Científica, a science consulting company active in the intersection between science, communication, and business. Also in 2017, he created Project Prometheus, designed to increase the chances of professional happiness for pre-university students, undergraduates, and graduate students. Dr. Belchior is the current Financial Director for Pint of Science Brazil, the biggest science festival in the world, responsible for attracting sponsors for the 2019 regional event.


References

  1. N. Bennet, G. J. Lemoine. What VUCA Really Means for You Harvard Business Review, 1-2: 2014.url: https://hbr.org/2014/01/what-vuca-really-means-for-you
  2. M. Sh. Hajirahimova, A. S. Aliyeva. About Big Data Measurement Methodologies and Indicators International Journal of Modern Education and Computer Science, 9(10): 1–9, 2017. | doi: 10.5815/ijmecs.2017.10.01
  3. U.S. Department of Education. Undergraduate Retention and Graduation Rates The Condition of Education 2018, May (NCES 2018-144): 200-204, 2018.url: https://nces.ed.gov/pubs2018/2018144.pdf
  4. European Commission/EACEA/Eurydice. The European Higher Education Area in 2018: Bologna Process Implementation Report Luxembourg, 2018.url: http://dx.doi.org/10.2797/091435
  5. Ministério da Educação. Censo da Educação Superior 2017 (Brasília): 2018.url: http://portal.inep.gov.br/web/guest/sinopses-estatisticas-da-educacao-superior
  6. N. Ghaffarzadegan, J. Hawley, R. Larson, Y. Xue. A Note on PhD Population Growth in Biomedical Sciences Systems Research and Behavioral Science, 32(3): 402–5, 2014. | doi: 10.1002/sres.2324
  7. K. Langin. In a first, U.S. private sector employs nearly as many Ph.D.s as schools do Science, 2019. | doi: 10.1126/science.caredit.aax3138
  8. P. Smaglik. Beating the odds to secure a permanent contract Nature, 562(7725): S49–51, 2018. | doi: 10.1038/d41586-018-06873-5
  9. The Royal Society. The Scientific Century - securing our future prosperity March: 2010.url: https://royalsociety.org/topics-policy/publications/2010/scientific-century/
  10. T. M. Evans, L. Bira, J. B. Gastelum, L. T. Weiss, N. L. Vanderford. Evidence for a mental health crisis in graduate education Nature Biotechnology, 36(3): 282–4, 2018. | doi: 10.1038/nbt.4089
  11. C. Woolston. Graduate survey: A love–hurt relationship Nature, 550(7677): 549–52, 2017. | doi: 10.1038/nj7677-549a
  12. K. Furnell. Breaking the silence around mental health Science, 2018. | doi: 10.1126/science.caredit.aav5324
  13. F. Aguisanda. Grad school depression almost took me to the end of the road—but I found a new start Science, 2018. | doi: 10.1126/science.caredit.aaw2136
  14. Nature, 559(7714): 302, 2018. | doi: 10.1038/d41586-018-05745-2
  15. B. Roscoe, I. Soares. Desemprego entre mestres e doutores no Brasil Correio Braziliense, 10/03/2019 [online]: 2018.url: https://www.correiobraziliense.com.br/app/noticia/brasil/2019/03/10/interna-brasil,741968/desemprego-entre-mestres-e-doutores-no-brasil-chega-a-25.shtml
  16. A. Levine. Allow me to tell you how awesome you are Science, 2019. | doi: 10.1126/science.caredit.aax1181
  17. J. Hedge. Working Scientist podcast: Learn to code to boost your research career Nature Careers Podcast, 11 APRIL [online]: 2019.url: https://www.nature.com/articles/d41586-019-01187-6
  18. J. Mervis. How much do graduate students benefit from studying abroad? Science, 2019. | doi: 10.1126/science.aaw5871
  19. C. Harrison. To find the right career fit, I needed to do more than move from job to job Science, 2019. | doi: 10.1126/science.caredit.aax4076
  20. K. Langin. How mindfulness can help Ph.D. students deal with mental health challenges Science, 2019. | doi: 10.1126/science.caredit.aax4909
  21. K. Bodewits. You’ve accomplished more than you think Science, 2019. | doi: 10.1126/science.caredit.aax5688
  22. C. Woolston. Postdoctoral mentorship key to career success Nature, 565(7741): 667, 2019. | doi: 10.1038/d41586-019-00262-2
  23. C. Romeo Upperman. From academia to industry: seven tips for scientists making the leap Nature, 2019. | doi: 10.1038/d41586-019-00692-y

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The Electronic Lab Notebook: Am I going have one?

Submitted by redoxoma on Thu, 02/28/2019 - 18:06
The electronic lab notebook

Main Article by Percíllia Oliveira and Patricia Nolasco

Communication is at the heart of science throughout all stages of work development. Ideas, evidences, experimental findings have to be shared and discussed among students or post-docs themselves and with their supervisors, as well among collaborating groups, funding agencies and in some cases the industry, long before they are externally communicated to the public. Paper laboratory notebooks have been at center stage of this scientific communication. Science starts and gains life in those pages. Science starts and gains life in those pages What is written there is fundamental documentation to provide a safe basis for assessing at any time the collection of observations, accompanied by crucial experimental details, which underlie the rite of passage of a hypothesis to results that are negative or positive, failed or successful, correctly or incorrectly interpreted, etc. But the essential element in the lab notebook is the data. Immutable and solid as they should be. From there, the results are assembled into scientific papers, go to meeting presentations, construct scientific contributions and in some cases serve as the basis for patents and turn into applications. It runs between the naïve and ironic to consider that vast implications ranging from novel worldwide research avenues to drug developments that cost millions — and directly reflect in the lives of many patients and the public in general — are based solely on the good faith that experiments in fact occurred as they are written in a lab notebook.

Thus, the lab notebook remains the crucial depository of raw scientific advances. However, human writing is not always easy to understand/interpret, the paper media is slow to write, its information is tedious to retrieve, it is environmentally unfriendly and very hard to store on a large scale basis for prolonged periods of time. Moreover, it is always possible to forget documenting crucial information. And the physical media has its intrinsic fragility. Moreover, as scientists deal with increasing volumes of data, such as in Systems Biology or Big Data, paper notebooks have indeed become inefficient and can be viewed as archaic. In addition, the increasing concerns over reproducibility of scientific experiments, as well as data manipulation, have promoted a significant upscaling in the documentation standards required from funding agencies and publications.

Can you easily find the previous data?Furthermore, from a practical standpoint, let's put ourselves into the skin of a young student or post-doc. The first thing that happens when you join a lab is to receive a book which you should take care as much as your own life, because all your work during graduation and ensuing years will be on those sheets. In the beginning, keeping the lab notebook is relatively effortless and it even seems simple. Until time starts to pass faster and faster and, maybe in one week or in 3 years, you need to replicate some experiment. Can you easily find the previous data? Are you sure this will be possible using just lab your notebook notes? Can you decipher all notes and drafts? And if something happens with your lab notebook? And why did you forget to write that small detail that has now become critical? In many cases you start to wish you were that kind of person who would take organized notes of everything at the very moment they happen. And then you may remember that everybody told you that — today more than ever — we must be quite focused to be organized and document everything we did in the lab using precise rules. And you might feel guilty and more than ever part of a huge party named… human beings.

Thus, further solutions to the lab notebook are a logical and needed step to improve the accuracy, accessibility and ability to reproduce raw scientific results. In a logical sequence of events, electronic lab notebooks (ELNs) have come up to fulfill this gap and are growing steadily. Historically, the idea of a paperless lab has been a promising development since the early 1990s.ELN will replace the way scientific information is kept It is expected that ELN will replace the way scientific information is kept, facilitating reproducibility, long-term storage and availability of experimental records across multiple devices (e.g. phones, computer, tablets) and also providing interfaces to instrumentations through integration with all digital data and images. In particular, ELNs may logically facilitate investigator adherence to best practices in data documentation. Other relevant aspects of ELN include easy data sharing and backups, search algorithms, enhanced transparency and a way to protect intellectual property by ensuring that records are properly dated and maintained. Indeed, ELNs can be very useful for knowledge management, by housing all raw research-related files (notes, data, results, graphs, images, etc) in a unique local; this provide an easy tool to browse and search through these experiments as a whole, up to years later.

Currently there is a wide range of ELNs in the market (ca.72 versions available among free and paid to use), covering different areas within Chemistry and Biology within most active knowledge domains. Furthermore, there are generic note-taking products, which have been evaluated for use as ELNs such as Evernote and Onenote. In addition, several investigators have been using cloud storage such Dropbox and GoogleDrive as well, which are reasonable options depending on the type of laboratory and data to be stored or exchanged. The best-rated ELNs available, according to a systematic search by a Life Sciences news website (Splice [7]) include SciNote, Benchling, RSpace, Docollab, LabFolder, LabArchives, Mbook Labguru and Hivebench. Also, many universities and research institutes have started to provide ELNs to their investigators, for example VIB Institute in Belgium [8]. Each lab has its own set of expectations, intentions, needs and capabilities, which will most likely never be fulfilled by a single universal ELN but may be satisfactorily addressed by one of these possibilities.

Despite the large ELN portfolio and their advantages, a number of scientific labs still prefer paper over digital technology and the majority of them are likely still handwriting on paper notebooks and continue to paste tables and gel figures on them. In some other cases, research labs are still struggling with mixed success to introduce ELNs or digital data management into their teams. These difficulties can be accounted for by a number of reasons, including: resistance or fear to give up the security blanket of paper lab notebooks; inertia to change established practices (i.e. documentation, storage data), especially in the middle of an ongoing research project; lack of information about how ELNs work; extra time needed to start learning to use ELNs; lack of encouragement and support from supervisors to the use of ELNs by their students; finally, the feeling that all is well, why change it? — even if all is not well, as we will see in the next paragraph. These points highlight the main issues about widespread adoption of ELNs. However, each lab has its own issues and challenges to introduce ELNs in the routine. In this way, there is no best preferred approach to get started. In general, however, it would be great to start addressing this issue and instigate students and post-docs to get involved in ELN practices as soon as possible. Today’s early-career researchers, undergraduates and PhD students who have grown up with digital technology, preferentially tend to embrace electronic solutions. However, adoption of ELNs demands more than just a fine technology but a change of attitude and organization. For beginning students, it would be great to adopt ELNs from the start of their projects. Nevertheless, a parallel structure to support the old ones who have to do the transition appears essential. Also, it seems important to encourage new students to try distinct ELNs to find one that better suits the needs of the lab. Another alternative is to have one person in the lab designated to set up the best tool and then introduce it to the whole team. It is important to realize that the transition from paper to ELNs is not going to happen overnight: each lab needs to establish a model. In this process, adopting a balanced integration between electronic and paper format has been considered a better approach than the sudden replacement of paper by ELNs. Perhaps, adopting cloud storage may be a useful first approach to a number of labs. Overall, some companies marketing ELNs advertise that about 15-20% working time could be saved by adoption of ELNs. This number, as far as we know, has not been validated, but could be encouraging.

During the first entrepreneurship course developed in University of São Paulo School of Medicine (September to November/2018, Prof. Flávio Grynszpan) we focused into ‘ELN world’ and, in this process, we interviewed 31 science-related individuals including PIs, post-docs, PhD and master students, technicians and associated researchers. Surprisingly, most of them (>90%) did not even know about ELNs. Even more surprisingly, contrarily to the best investigative practices, the vast majority of interviewed investigators (excluding the PIs in this case) use scratch-paper notes to record their experiments and their processes and organizational structures for these notes are quite different. They usually update their lab notebooks daily (37%) or at least once a week (29%) and the others (34%) do not write up their experiments frequently, in some cases possibly not at all (our guess…). Almost uniformly, they were very interested in the idea of getting into the ‘ELN world’. Thus, a striking conclusion from this small sample is that in parallel with best ways to record experimental results, one has to struggle to implant good practices in data recording. We expect that ELNs will be of great help also along this direction.

sometimes some disruption is necessary to achieve progressOverall, the trend towards the ELN is taking force: it is an exciting time to try these tools in research and to get involved into a new era of information and science propagation. ELN implantation has a clear potential to address several questions related to improve accuracy and possibly reproducibility of science. In parallel, we acknowledge it is not so easy to move away from ingrained habits, but sometimes some disruption is necessary to achieve progress. Along this line, the most effective way to adopt ELNs may be… just do it !! …and then harvest the rewards of an improved work.


References and additional information

  1. J. Giles. Going paperless: The digital lab Nature, 481(7382): 430–1, 2012 | doi: 10.1038/481430a
  2. D. Butler. A new leaf Nature, 436(7047): 20–1, 2005 | doi: 10.1038/436020a
  3. H. K. Machina, D. J. Wild. Electronic Laboratory Notebooks Progress and Challenges in Implementation Journal of Laboratory Automation, 18(4): 264–8, 2013 | doi: 10.1177/2211068213484471
  4. R. Kwok. How to pick an electronic laboratory notebook Nature, 560(7717): 269–70, 2018 | doi: 10.1038/d41586-018-05895-3
  5. S. Guerrero, G. Dujardin, A. Cabrera-Andrade, C. Paz-y-Miño, A. Indacochea, M. Inglés-Ferrándiz, H. P. Nadimpalli, N. Collu, Y. Dublanche, I. De Mingo, D. Camargo. Analysis and Implementation of an Electronic Laboratory Notebook in a Biomedical Research Institute PLOS ONE, 11(8): e0160428, 2016 | doi: 10.1371/journal.pone.0160428
  6. S. Kanza, C. Willoughby, N. Gibbins, R. Whitby, J. G. Frey, J. Erjavec, K. Zupančič, M. Hren, K. Kovač. Electronic lab notebooks: can they replace paper? Journal of Cheminformatics, 9(1): , 2017 | doi: 10.1186/s13321-017-0221-3
  7. Splice website: splice-bio.com/the-7-best-electronic-lab-notebooks-eln-for-your-research/
  8. VIB Institute ELN webpage: www.vib.be/en/training/VIB%20Informatics/Pages/ELN.aspx
  9. Newsletter SciNote: scinote.net/blog/paper-and-electronic-lab-notebooks-can-work-together/

List of cited ELN websites

Percíllia Victória Santos de Oliveira (perc-I-am-here-illia.oliveira@hotmail.com@gmail.com) and
Patricia Nolasco Santos (pat-I-am-here-ty_ns8@@gmail.com@hotmail.com),
PhD students from the Vascular Biology Laboratory, Heart Institute (Incor), University of São Paulo, Brazil


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