Succinate accumulates during ischemia forcing mitochondrial complex I to operate in reversal, while producing oxidant species during reperfusion

by José Carlos Toledo

Ischemia-reperfusion (IR) is a process where blood supply (thus oxygen supply) to an organ is interrupted and then restored. While reperfusion is essential for survival, it is accompanied by a burst of mitochondrial generation of redox species and intermediates such as superoxide and hydrogen peroxide. Such species associate with derived ischemic tissue injury, underling disorders such as heart attack and stroke [1]. Nonetheless, IR mitochondrial ROS production has been considered a nonspecific consequence of a dysfunctional interaction of mitochondrial redox


ROS are not good for our minds

Ohara Augusto
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo

You may be thinking that the above title means that ROS are bad to our central nervous system because they trigger oxidative reactions that can damage it. Instead, the message here is that the term ROS obscures the mind to the point of hindering the advances in the understanding of the multiple roles of free radicals and oxidants in physiology and pathophysiology.

ROS appeared as an abbreviation for Reactive Oxygen Species but abbreviations are useful when they have specific meanings. ROS is not truly an abbreviation because it groups together molecules with entirely different chemical and biological properties. Also, it is not accepted as a standard abbreviation in chemistry because