Calorie Restriction can protect the brain

Redoxcope: Interview | M. C. WiderCalorie Restriction Can Protect the Brain

by Maria Celia Wider

For decades, caloric restriction has been known to enhance longevity and the prevent age-related diseases. However, the processes responsible for these effects are not yet fully understood. Now, Redoxoma Network researchers have found the mechanism in which caloric restriction facilitates mitochondrial calcium retention capacity in the brain, resulting in protection against excitotoxic damage, which is related to neuronal loss in diseases such as stroke, Parkinson´s and Alzheimer’s. “Because we determined caloric restriction´s mechanism of action, we may be able to develop drugs to increase mitochondrial calcium uptake in mitochondria in a manner that is not dependent


An unexpected antiinflammatory route involving Nox2 NADPH Oxidase and thioredoxin

Redoxoma Highlights | F. LaurindoAn unexpected antiinflammatory route involving Nox2 NADPH Oxidase and thioredoxin

Nox NADPH oxidases are major sources of signaling oxidants in a variety of cell types, while in phagocytes Nox2 is essential for microbial killing and host defense. Genetic mutations impairing the Nox2 complex in humans associate with chronic granulomatous disease, a severe immunodeficiency that courses, however, with a paradoxical proinflammatory state. Recent work involving a cooperation between 2 CEPIDs, the Center for Research in Inflammatory Diseases (Fernando Q. Cunha) and Redoxoma (Lucia R Lopes) helped shedding light onto this complex phenomenon [1]. The investigators showed that during Nox2 activation, there is


Innovation Corner


Enhanced mechanistic knowledge is a major aim of our CEPID-Redoxoma, well in line with the Redoxcope text of the present Newsletter issue. In parallel, at the other end of the spectrum, stands innovation, which is our interface with Society. Enhancing innovation is a prime objective of our science and technology system and a major component of the CEPID agenda. Our CEPID-Redoxoma is advancing into these fronts and we hope to turn such efforts into concrete achievements. To get an overview of the patent applications filed in the course of, or in connection with, our Redoxoma investigations, please share the following link:


CEPID-Redoxoma marks its presence in SBBq / IUBMB 2015

Redoxoma’s booth attracted hundreds of students

contributed by
Maria Célia Wider

The stand ridden by CEPID-Redoxoma at the 23rd Congress of the International Union of Biochemistry and Molecular Biology (IUBMB) and 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology (SBBq) was a success and attracted hundreds of students and researchers from various Brazilian states and several countries, interested in knowing the Center.

The team formed by Tsai Araujo, Camille Caldeira, Edlaine Linares and Maria Celia Wider was responsible for the dissemination of CEPID-Redoxoma activities and distributed folders with information on the group’s researchers and their projects



I am very excited to present our second number of our Redoxoma Newsletter. You will soon notice why. First, we have grown bigger, indicating that this newsletter is already turning into a good vehicle for communicating ourselves around the science of redox processes. Second, we have exciting comments on scientific productions from our Redoxoma team, and I am glad to know we have even more in the pipeline. In addition, we bring selected highlights from the literature which are likely to be of interest to everyone. Remarkably, some of these were brought about by young investigators from our team. My special thanks to them: you are more


Education page

Education page:
by Carmen Fernandez

by Carmen Fernandez

The CEPID-Redoxoma group had significant participation during events promoted by Universidade de São Paulo (USP) at the end of 2014 – I Virada Científica; Semana Nacional de Ciência e Tecnologia e 31ª Semana da Química. A folder about the project CEPID-Redoxoma was distributed to students and public in general during these events (Figure 1).

I Virada Científica was created by USP with the goal of making the world of science and technology closer to the São Paulo society. The event lasted 24 hours, starting 8am on October 11, and included workshops, experiments, shows, games, lectures, films and planetarium sessions – much of it aimed at children. Admission


Development of a PDT protocol that avoids amputations in the diabetic feet

by Mauricio da Silva Baptista

Photoinduced reactions can be used to treat diseases such as cancer or microbial infections in a process called Photodynamic therapy. There are several indications of PDT in the areas of dermatology, oncology, vascular, blood supplies, ophthalmology. In addition to performing research in basic science related with PDT, CEPID Redoxoma researchers work in partnership with physicians, participating on clinical studies that aim to prove the potential of PDT in clinical medicine as can be seen in article published in 2014 [1]. There are several characteristics


Mitochondrial metabolism and central nervous system dysregulation govern an overeating but low energy conversion efficiency response to intermittent-feeding

The ideal type of diet is a long-sought goal that has not been fulfilled so far, both for preventive as well as therapeutic purposes. At the same time, caloric restriction has been well demonstrated to afford increase in lifespan in several species. Intermittent feeding has been used as a substitute for caloric restriction both by overweight or obese individuals (frequently without medical supervision) or, experimentally, as a mechanistical tool to understand the physiology of lifespan extension. These intermittently-fed animals, indeed display decreased body mass, but surprisingly overall caloric intake is similar to that of ad libitum-fed animals. Work performed by the CEPID-Redoxoma


Photochemistry in the dark governs pathways for singlet oxygen generation

Excited species such as singlet molecular oxygen [O2(1Δg)] and triplet carbonyls are a less understood subgroup of oxygen-derived oxidants in BioMedicine. Their generation has been associated to the detection of ultraweak chemiluminescence in mammalian tissues and there is emerging evidence for their roles in pathophysiological situations. However, pathways accounting for their generation in vivo have remained obscure, limiting the assessment of their biological roles. In vitro, excited species arise from photochemical processes involving direct excitation by light. However, atypical photochemical processes not involving photoexcitation have been proposed


Alicia Kowaltowski wins the Capes-Elsevier award

Alicia Kowaltowski, Full Professor at the Instituto de Química, Universidade de São Paulo, and member of the INCT and CEPID of Redox Processes in biomedicine – Redoxoma, was one of the winners of 2014 Award Capes-Elsevier. The award ceremony was held at the Copacabana Palace in Rio de Janeiro, last May.

The award is a partnership between Elsevier and the Coordination of Improvement of Higher Education Personnel, Ministry of Education (CAPES / MEC). This year, ten women scientists received the award for their contribution to the development of science in Brazil.

The criteria for the selection of the winners was researchers who have impacted the scientific community, published articles