Free radicals: should clinicians pay attention to them?

by Protasio L. da Luz*

Within the Cepid-Redoxoma, we are deeply involved in redox research and we consider this very important, of course. However, it is interesting at times to see how some meaningful outsiders interpret the area. The Radical-Free Corner challenged a highly experienced academic clinician-scientist, who kindly accepted this task (he happens to have been the Editor’s doctorate supervisor – a minor conflict of interest, I confess)

(Editor’s comment)

Oxidative stress pervades several areas of Medicine: aging, cancer, atherosclerosis and other degenerative conditions, principally. Several studies claim that it is the cause of aging. But while there is evidence for


A novel ubiquitin-related marker in oxidative stress response

by Marilene Demasi

Protein polyubiquitination was first described as a post-translational modification to direct proteins for degradation. The ubiquitin molecule is covalently bound to the target protein and the polyubiquitin chain is created by successive attachments of ubiquitin through its carboxy-terminal Glycine mainly to Lysine48 (K48) residues of previously conjugated ubiquitin. Proteins tagged with a K48-linked polyubiquitin chain are directed for degradation. However, distinct ubiquitin chains are built up through other Lysine residues from ubiquitin, resulting in distinct structural patterns of ubiquitin complexes, which in most cases are unrelated to target protein degradation.