What is in a mechanism?

Francisco R. M. Laurindo
Vascular Biology Laboratory, Incor
University of São Paulo Medical School

If you care about science, you care about mechanisms. Or at least you should, if you care about doing good science. More than ever, there is a wide consensus that the quality of science is as good as the depth of mechanistic insights it carries. Powerful mechanisms appear everywhere: in articles from top journals, in discussions with good scientists, in decisions about grant priorities, academic career, etc. This is also uncomfortably felt in the rejection letters one gets nowadays, in which the lack of sufficient mechanistic insights is a chief reason for not achieving a high-impact publication