We are back after a longer while than we expected. As with redox processes themselves, this delay was caused by good and bad things. The bad ones were a recurrent problem with our server, which caused our Newsletter to repeatedly get out of access. Hopefully it will be stable from now on, just as we hope to happen with redox homeostasis. The good things were recurrent bouts of very very hard work for our Editor, as well as for our colleagues, as chairs and organizers of international meetings, editors, authors of original as well as review articles, assistants for our research agencies , etc in addition of course to the usual duties at our universities. Similar to redox processes, we hope
While the intuitive idea is that the lumen of diseased blood vessels narrows due to the pathological growth of a migrating cell mass, similar to rust in an old pipe, actually the lumen of diseased vessels is strongly influenced by a phenomenon called vascular remodeling, the structural reorganization of whole-vessel circumference. Typically, remodeling is the sole determinant of vessel lumen due to blood flow changes, in which redox signaling processes play an important mediator role in association with NO biovailability. However, redox processes appear to mediate other forms of vascular remodeling as well, such as those associated with atherosclerosis-related processes. We showed previously
Duality. That is the word of order of this issue of our Newsletter. Dual roles of enzymes as anti or prooxidants, dual roles of autophagy to protect or kill cancer cells, dual roles of redox processes to signal physiological processes or to contribute to disease-promoting mechanisms, and so on. Duality is not surprising, as we see that all along nature. But it is confusing to the scientist, who for sure would love to classify processes as either beneficial or damaging, given the pattern-seeking way our minds are structured. Things become even more confusing in the redox biology/chemistry area, given the several extra levels at which a given process can bifurcate across the “light-or-dark”
Francisco R. M. Laurindo
Vascular Biology Laboratory, Incor
University of São Paulo Medical School
If you care about science, you care about mechanisms. Or at least you should, if you care about doing good science. More than ever, there is a wide consensus that the quality of science is as good as the depth of mechanistic insights it carries. Powerful mechanisms appear everywhere: in articles from top journals, in discussions with good scientists, in decisions about grant priorities, academic career, etc. This is also uncomfortably felt in the rejection letters one gets nowadays, in which the lack of sufficient mechanistic insights is a chief reason for not achieving a high-impact publication
Enhanced mechanistic knowledge is a major aim of our CEPID-Redoxoma, well in line with the Redoxcope text of the present Newsletter issue. In parallel, at the other end of the spectrum, stands innovation, which is our interface with Society. Enhancing innovation is a prime objective of our science and technology system and a major component of the CEPID agenda. Our CEPID-Redoxoma is advancing into these fronts and we hope to turn such efforts into concrete achievements. To get an overview of the patent applications filed in the course of, or in connection with, our Redoxoma investigations, please share the following link: http://redoxoma.iq.usp.br/kfile_arquivo.php?id=1419
It is exciting to realize that the Newsletter is establishing itself as a communication vehicle between the Redoxoma group and a now expanded array of colleagues from Brazil and abroad. Welcome to all of you.
Thanks to the work of many colleagues, we have very exciting contributions, which emanate from research supported by our CEPID-Fapesp. In this issue, we can walk through intriguing paths, starting really from the beginning – with redox threads to the origin of life! And we end in a bold way, with a short essay from an experienced academic clinician, on how he interprets our redox area – leading us to think over where we should at the end direct our efforts. In
by Denise C. Fernandes
Correct protein folding is a vital and extremely regulated cellular function. Disulfide bonds are essential determinants of the correctly folded protein structure. During the folding of nascent proteins into the endoplasmic reticulum (ER) lumen, essential enzymes promote disulfide bond insertion (oxidation) and their eventual repositioning (isomerization) when they are initially formed between wrong cysteines. These reactions are catalyzed by PDIs (protein disulfide isomerases), a family of enzymes that contains more than 20 members, from yeast to humans . Thus, PDIs do not have one specific substrate, but rather a large variety of un/misfolded protein substrates.
I am very excited to present our second number of our Redoxoma Newsletter. You will soon notice why. First, we have grown bigger, indicating that this newsletter is already turning into a good vehicle for communicating ourselves around the science of redox processes. Second, we have exciting comments on scientific productions from our Redoxoma team, and I am glad to know we have even more in the pipeline. In addition, we bring selected highlights from the literature which are likely to be of interest to everyone. Remarkably, some of these were brought about by young investigators from our team. My special thanks to them: you are more
by Francisco Laurindo
Can professionalism be learned? Certainly, to some extent, but likely not in the way you learn Chemistry or Biology, for example. But you can – and you should – discuss it, in order to trigger further thoughts that can help to achieve personal improvement. This is the idea of this short essay, derived from lectures given at our annual retreats over the years. While written with the young student in mind, I think it fits other ages as well… It should not be read rationally, but emotionally, just like it was written.
A general feeling among scientists is that science is not for everyone and that the scientific career is unusual in many aspects. To a good extent