Calorie Restriction can protect the brain

Redoxcope: Interview | M. C. WiderCalorie Restriction Can Protect the Brain

by Maria Celia Wider

For decades, caloric restriction has been known to enhance longevity and the prevent age-related diseases. However, the processes responsible for these effects are not yet fully understood. Now, Redoxoma Network researchers have found the mechanism in which caloric restriction facilitates mitochondrial calcium retention capacity in the brain, resulting in protection against excitotoxic damage, which is related to neuronal loss in diseases such as stroke, Parkinson´s and Alzheimer’s. “Because we determined caloric restriction´s mechanism of action, we may be able to develop drugs to increase mitochondrial calcium uptake in mitochondria in a manner that is not dependent