The complex relationship between omega-3 fatty acids and neurodegenerative diseases

by Sayuri Miyamoto

Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is well known by its health-promoting effects. Being highly abundant in the brain, DHA displays essential role in neurological and visual development in infants. In adults, the decline of DHA content in brain has been associated to cognitive impairment and the use of omega-3 supplements have been thought to exert neuroprotective effects. Indeed, some studies indicated that consuming DHA would be beneficial for the prevention of cognitive disorders such as Alzheimer’s disease [1]. However, a recent clinical study involving 4000 participants has


Together for ever…: Cross-linking of proteins by a ditryptophan bond

Cross-linking of proteins by a ditryptophan bond

by Verônica Paviani

Oxidative modifications of proteins are extensively investigated because proteins are major targets of radicals and oxidants under physiological conditions [1]. The amino acid residues most susceptible to oxidation are the sulfur-containing residues cysteine and methionine and the aromatic residues histidine, phenylalanine, tyrosine and tryptophan. The oxidation of cysteine and methionine residues is reversible and protein-cysteine oxidation is emerging as a fundamental cell regulatory mechanism. In contrast, the oxidation of all other protein residues is irreversible, and may result in loss of protein


Education Page

During the event “II Virada Científica” promoted by University of São Paolo at October, 17th and 18th the CEPID-Redoxoma group was Involved in science diffusion activities. About 160 people visited our activities during the event. The contribution of Cepid Redoxoma occurred in promoting experiments in a dark room named “Free, radicals and light”, two lectures named The fat, the slim and healthy – a conversation about metabolism, Sex, Chemistry and Power and presenting two educational games – Electron Transport Chain and ChemCards. Experimental activities were designed for an audience of children, youth and adults, many of them families. Four experiments were conducted


Innovation Corner


Enhanced mechanistic knowledge is a major aim of our CEPID-Redoxoma, well in line with the Redoxcope text of the present Newsletter issue. In parallel, at the other end of the spectrum, stands innovation, which is our interface with Society. Enhancing innovation is a prime objective of our science and technology system and a major component of the CEPID agenda. Our CEPID-Redoxoma is advancing into these fronts and we hope to turn such efforts into concrete achievements. To get an overview of the patent applications filed in the course of, or in connection with, our Redoxoma investigations, please share the following link:


How I see the future of redox research

Henry Jay Forman

by Henry Jay Forman

With this issue, we start a series of short texts about the theme “How I see the future of redox research”. The radical-free corner was really radical in this regard and invited several prominent colleagues from Brazil and abroad. These comments are meant to be highly personal accounts, by known experts, of the directions they foresee redox research. We are sure these short insertions will kick on our minds to help our thinking.

And we started in great style, with no one less than Prof. Henry Jay Forman, a long-standing investigator of the area. Prof. Forman is the Distinguished Professor of Chemistry and Biochemistry, University of California, Merced, and the former


The two faces of peroxiredoxins

by Larissa Anastácio da Costa Carvalho

In the antiquity, many cities protected their territories by surrounding fortifications, with giant gates and arches working as unique gateways. The Roman god Janus, known as the protector of entrances or new-beginnings, is represented by a head with two faces in opposite directions. The two faces of Janus symbolize the duality of nature. Well, nature itself is marked by dichotomy. What in nature cannot be good and bad at the same time? That is the origin of the term Janus effect.

A remarkable example of the Janus effect is the mustard gas (1,1-thiobis-2-chloroethane). Used as a chemical weapon during World War I, it causes serious inflammation of the


The controversy about antibiotic lethality and reactive oxygen species

by José Freire da Silva Neto

Antibiotics are powerful compounds in our battle against bacterial diseases. Despite their miraculous efficacy over decades, nowadays we are faced with the global spreading of antibiotic resistance and the decrease of our antibiotic arsenal. For many years, we learned that antibiotics exert their effect by direct interaction with different primary bacterial targets, causing killing (bactericidal drugs) or growth inhibition (bacteriostatic drugs). In 2007, an influential paper from the Collins laboratory [1] placed reactive oxygen species (ROS) as central players in the mechanism of cell death induced by bactericidal antibiotics. Ever since


Clipping News

Are the antioxidants a good call to prevent cardiovascular disease?

Because free radicals and reactive oxygen species are often not selective and highly reactive, it is reasonable to think that substances that neutralize these molecules, or that counteract free radicals effects, would be beneficial in human health. Interestingly, this is not what the free radical researchers have found so far. The research headed by Professor Francisco Laurindo’s group, at the Instituto do Coração (Incor) Faculdade de Medicina da Universidade de São Paulo (FMUSP), has shown that the use of lipoic acid, a powerful antioxidant and nutritional supplement, increased aorta aneurism


CEPID-Redoxoma marks its presence in SBBq / IUBMB 2015

Redoxoma’s booth attracted hundreds of students

contributed by
Maria Célia Wider

The stand ridden by CEPID-Redoxoma at the 23rd Congress of the International Union of Biochemistry and Molecular Biology (IUBMB) and 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology (SBBq) was a success and attracted hundreds of students and researchers from various Brazilian states and several countries, interested in knowing the Center.

The team formed by Tsai Araujo, Camille Caldeira, Edlaine Linares and Maria Celia Wider was responsible for the dissemination of CEPID-Redoxoma activities and distributed folders with information on the group’s researchers and their projects


Calls for Applications

Cooperation between Brazilian research foundations and UK Academies stimulates the mobility of young UK scientists to visit research groups in Brazil to short-term (from 7 days to 12 months) and medium to long term (from 6 months to 36 months). For the São Paulo state, it is also offered an opportunity for young investigators from the UK to start a research career in a university or research institution in the State of São Paulo. The required documentation for the proposals must be submitted to FAPESP before October 23, 2015 (<span